In70 of Plasmid pAX22, a bla VIM-1 -Containing Integron Carrying a New Aminoglycoside Phosphotransferase Gene Cassette

Characterization of plasmid pAX22, encoding VIM-1 metallo-β-lactamase, reveals a new putative mechanism of In70 integron mobilization.

OBJECTIVES VIM-type enzymes are among the most widespread acquired metallo-β-lactamases among Gram-negative pathogens. Integron In70 is a class 1 integron that has emerged as a successful genetic support for blaVIM-1 (one of the most prevalent blaVIM allelic variants) in Gram-negative non-fermenters, and is usually chromosome borne. The objective of this study was to characterize plasmid pAX22 ...

Rickettsia felis in the United Kingdom

2. Pournaras S, Tsakris A, Maniati M, Tzouvelekis LS, Maniatis AN. Novel variant (bla(VIM-4)) of the metallo-β-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2002;46:4026–8. 3. Toleman MA, Rolston K, Jones RN, Walsh TR. Molecular characterization of VIM-4, a novel metallo-β-lactamase isolated from Texas: report from the CANCER surveillance ...

First characterization of bla(VIM-11) cassette-containing integron in metallo-beta-lactamase producing Pseudomonas aeruginosa in Malaysia.

New integron-associated gene cassette encoding a 3-N-aminoglycoside acetyltransferase.

A fifth gene cassette containing an aacC gene, aacCA5, was found in an aacCA5-aadA7 cassette array in a class 1 integron isolated from a multiply drug resistant Salmonella enterica serovar Kentucky strain. The AacC-A5 or AAC(3)-Ie acetyltransferase encoded by aacCA5 is related to other AAC(3)-I enzymes and confers resistance to gentamicin.

Characterization of In100, a new integron carrying a metallo-{beta}-lactamase and a carbenicillinase, from Pseudomonas aeruginosa.

In100, a new integron carrying a carbapenemase gene (bla(VIM-2)) associated with a carbenicillinase (blaP1b) and aminoglycoside resistance genes (aacA4 and aadA2), was detected in a Pseudomonas aeruginosa clinical isolate. The particular gene cassette organization of In100 seems to reflect the evolution of antibiotic usage in therapeutics.